ea0070ep31 | Adrenal and Cardiovascular Endocrinology | ECE2020
Romanova Natalia
, Selivanova Liliya
, Platonova Nadezhda
, Troshina Ekaterina
, Abrosimov Aleksander
CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. In addition, CY...